Endocrine Abstracts

A systematic survey of low S-cortisol levels at the department of clinical chemistry: indications for testing and frequency of undiagnosed adrenal insufficiency.Background: S-cortisol is frequently analyzed at clinical chemistry departments. Low levels of S-cortisol needs to be promptly acted on if the cause is undiagnosed adrenal insufficiency (AI). The causes of S-cortisol testing are however multiple and low levels are necessarily not alarming if foun...

Background & Objective: Late night salivary cortisol (LNSC) and 1 mg overnight dexamethasone suppression test (DST) are two of the three recommended screening tests for Cushing’s syndrome (CS). The classical DST uses serum cortisol, but analysis of salivary cortisol and cortisone has shown high diagnostic accuracy at DST (1). Salivary cortisol can be analysed with immunoassays, which suffer from variable degree of cross reactivity with other steroids, or with LC-MS/MS...